Synthesis of  trans ‐thienyl‐3‐ethoxycarbonyl‐2,3‐dihydro[1,5]benzothiazepin‐4(5 H )‐ones | Zendy

Letois Bertrand | Zendy; Lancelot Jean Charles | Zendy; Saturnino Carmela | Zendy; Robba Max | Zendy; De Caprariis Paolo | Zendy

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Synthesis of trans ‐thienyl‐3‐ethoxycarbonyl‐2,3‐dihydro[1,5]benzothiazepin‐4(5 H )‐ones

Author(s) -

Letois Bertrand,

Lancelot Jean Charles,

Saturnino Carmela,

Robba Max,

De Caprariis Paolo

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290716

Subject(s) - triethylamine , chemistry , hydrochloride , alkylation , order (exchange) , medicinal chemistry , organic chemistry , catalysis , business , finance

A series of trans ‐thienyl‐3‐ethoxycarbonyl‐2,3‐dihydro[1,5]benzothiazepin‐4(5 H )‐ones 6‐8 was synthesized from thienylmethylidenemalonates 3a‐3c and 2‐aminobenzenethiol 3d in the presence of triethylamine hydrochloride at 160°. The [1,5]benzothiazepines 6‐8 were alkylated using 2‐dimethylaminochloroethane, 3‐dimethylaminochloropropane and 3‐( N ‐piperidino)chloropropane in order to obtain the corresponding 5‐aminoalkylbenzothiazepinones 9‐14 .

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