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Synthesis of fluoro and trifluoromethyl derivatives of 2‐phenylquinolin‐4‐ol
Author(s) -
Janda Lubomir,
Nguyen Johnny,
Patterson Steven E.,
Strekowski Lucjan
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290713
Subject(s) - chemistry , trifluoromethyl , medicinal chemistry , organic chemistry , stereochemistry , alkyl
A tert ‐butoxide base‐mediated cyclization of fluoro‐ and trifluoromethyl‐substituted Schiff bases 12‐19 produces 4‐ tert ‐butoxyquinolines 23‐30 which are hydrolyzed to quinolin‐4‐ols 31‐38 .