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Synthesis of large‐ring lactams by a carbene‐anion bond forming reaction
Author(s) -
Williams Eric L.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290710
Subject(s) - chemistry , bicyclic molecule , carbene , ring (chemistry) , ion , lactam , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
Treatment of large‐ring lactams 1 with potassium t ‐butoxide results in the formation of bicyclic structures 2 . Evidence was obtained to support the formation of 2 through a carbene‐anion coupling. The structures of a series of bicyclic lactams 2 have been rigorously defined.