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The synthesis of a new benzothiazine derivative, related to oxicams, synthesized from natural safrole
Author(s) -
Fraga Carlos A. M.,
Barreiro Eliezer J.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290652
Subject(s) - safrole , chemistry , benzothiazine , derivative (finance) , organic chemistry , chromatography , financial economics , economics
The synthesis of the new derivatives, 2‐methyl‐6,7‐methylenodioxy‐2 H ‐1,2‐benzothiazin‐3‐one‐4‐( N ‐phenyl)carboxamide 1,1‐dioxide ( 6a ) from natural safrole ( 5 ) is described. The principal feature of this route is brevity and the high overall yield, producing the new analogue in ca. 35% from the natural product.