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Selective N ‐methylation of ethyl esters of 3‐(1 H ‐imidazol‐4‐yl)‐2‐propenoic acid
Author(s) -
Mawlawi H.,
Monje M. C.,
Lattes A.,
Rivère M.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290643
Subject(s) - chemistry , phenacyl , methylation , nitrogen atom , nitrogen , ethyl ester , medicinal chemistry , organic chemistry , group (periodic table) , biochemistry , dna
Methods of selective methylation of the nitrogen atoms of the ethyl ester of 3‐(1 H ‐imidazol‐4‐yl)‐2‐propenoic acid are reported. The nitrogen atom α to the ethylenic chain was methylated after protection of the β nitrogen with a phenacyl group.
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