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1‐Chloro‐2‐azapropenylium and 1‐chloro‐2,4‐diazabutenylium salts. Intermediates for the synthesis of pyrido[1,2‐ a ]‐1,3,5‐triazinium salts
Author(s) -
Okide George Bosah
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290630
Subject(s) - chemistry , perchlorate , yield (engineering) , medicinal chemistry , phosphorus , organic chemistry , ion , materials science , metallurgy
1‐Chloro‐1,3‐bis(dimethylamino)‐3‐phenyl‐2‐azaprop‐2‐en‐1‐ylium perchlorate obtained from the reaction of phosphorus oxychloride‐ N,N ‐dimethylbenzamide complex and dimethylcyanamide reacts with 2‐amino‐4‐methylpyridine to yield 8‐methyl‐4‐dimethylamino‐2‐phenylpyrido[1,2‐ a ]‐1,3,5‐triazinium perchlorate ( 8 ). The structure is established by X‐ray crystallography. Various suitably substituted pyridines react similarly to afford the corresponding pyrido[1,2‐ a ]‐1,3,5‐triazinium salts. The intermediates obtained from several secondary amides give identical products when treated with the same pyridines. The limitations of this procedure are investigated.