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Enantiospecific activity of tetracyclic PAF‐antagonists
Author(s) -
Walser A.,
Flynn T.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290619
Subject(s) - chemistry , enantiomer , platelet activating factor , stereochemistry , biological activity , in vitro , biochemistry , medicine
The syntheses of two enantiomeric tetracyclic compounds, the thieno[3,2‐ f ][pyrrolo[2,1‐ c ][1,2,4]triazolo[4,3‐ a ][1,4]diazepines 10a and 10b are described. Testing of these enantiomers as inhibitors of platelet activating factor (PAF) revealed good enantiospecificity, meaning that one enantiomer is responsible for the observed biological activity.