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Synthesis of indolizines and pyrrolo[2,1‐ b ]azoles from 2‐pyridylmagnesium bromide and 2‐lithiated azoles using tris(alkylthio)‐cyclopropenyl cations as a three‐carbon building block
Author(s) -
Kojima Hideo,
Yamamoto Kazuhiko,
Kinoshita Yasuo,
Inoue Hiroo
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290618
Subject(s) - chemistry , tris , bromide , block (permutation group theory) , medicinal chemistry , combinatorial chemistry , organic chemistry , biochemistry , geometry , mathematics
A convenient method for the preparation of indolizines 3 and 4 and pyrrolo[2,1‐ b ]azoles 7a‐e from 2‐pyridylmagnesium bromide and 2‐lithiated azoles 6a‐e , respectively, was developed by using tris( tert ‐butylthio)‐ and tris(isopropylthio)cyclopropenyl cations 1 and 2 as a three‐carbon building block.