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A facile preparation of 2‐(2‐arylethyl)‐ and 2‐(aminomethyl)indoles
Author(s) -
Nagarathnam Dhanapalan
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290601
Subject(s) - chemistry , yield (engineering) , cleavage (geology) , medicinal chemistry , catalysis , combinatorial chemistry , organic chemistry , materials science , geotechnical engineering , fracture (geology) , engineering , metallurgy
An important process for the acid catalyzed cleavage of the benzoyl group from 3‐benzoylindoles in high yield is identified and its application for the facile syntheses of 2‐substituted indoles is demonstrated by preparing some 2‐(2‐arylethyl)‐ and 2‐(aminomethyl)indoles from 1,3‐dibenzoyl‐2‐bromomethylindole (7).