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Synthesis of 3‐substituted‐1‐methylpyrazoles
Author(s) -
Pavlik James W.,
Kurzweil Edyth M.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290551
Subject(s) - chemistry , butyllithium , ring (chemistry) , quenching (fluorescence) , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , fluorescence , physics , quantum mechanics
Reaction of 3‐bromo‐1‐methylpyrazole 1 with t ‐butyllithium at − 100° followed by quenching of the lithiopyrazole intermediate allows regiospecific introduction of substituents into the 3‐position of the 1‐methylpyrazole ring.