Isoindole derivatives from 2‐isonicotinoyl‐acetophenone with ammonia and its derivatives | Zendy

Nan'Ya Seiko | Zendy; Kitahara Takeo | Zendy; Kuroda Taro | Zendy; Butsugan Yasuo | Zendy

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Isoindole derivatives from 2‐isonicotinoyl‐acetophenone with ammonia and its derivatives

Author(s) -

Nan'Ya Seiko,

Kitahara Takeo,

Kuroda Taro,

Butsugan Yasuo

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290540

Subject(s) - chemistry , isoindole , acetophenone , ammonia , adduct , aqueous solution , medicinal chemistry , derivative (finance) , glycine , iodide , organic chemistry , amino acid , catalysis , biochemistry , financial economics , economics

2‐Isonicotinoylacetophenone (1) reacts with aqueous ammonia in the presence of acid to produce the deep blue 3‐(4‐pyridyl)‐1‐[3‐(4‐pyridyl)‐1 H ‐1‐isoindolylidenemethyl]‐2 H ‐isoindole which changed to the deep bluish green adduct showing the wavelength maximum at 744 nm by treating with methyl iodide. From the reaction of 1 and glycine or its methyl ester the red 3,3′‐di‐(4‐pyridyl)‐1,1′‐vinylenebis(2 H ‐2‐isoindoleacetic acid) or its derivative were obtained respectively.

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