The preparation of perfluoroaryl substituted isoxazoles  via  nucleophilic aromatic substitution with lithioalkylisoxazoles | Zendy

Xia Xiongbing | Zendy; Knerr Gary | Zendy; Natale N. R. | Zendy

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The preparation of perfluoroaryl substituted isoxazoles via nucleophilic aromatic substitution with lithioalkylisoxazoles

Author(s) -

Xia Xiongbing,

Knerr Gary,

Natale N. R.

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290539

Subject(s) - chemistry , substituent , metalation , moiety , hexafluorobenzene , nucleophilic aromatic substitution , nucleophilic substitution , amide , medicinal chemistry , substitution reaction , substitution (logic) , stereochemistry , organic chemistry , benzene , computer science , programming language

The lithioalkylisoxazoles obtained from C‐5 lateral metalation of alkylisoxazoles, 1 , add to hexafluorobenzene. When the C‐4 substituent was an electron withdrawing tertiary amide moiety, the yields were highest for mono‐perfluoroarylation to give 5‐pentafluorophenylmethylisoxazoles, 2 .

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