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Studies on pyrrolidones. Synthesis and N ‐alkylation of β‐enaminoesters derived from pyroglutamic acid
Author(s) -
Fasseur Dominique,
Rigo Benoît,
Leduc Catherine,
Cauliez Pascal,
Couturier Daniel
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290537
Subject(s) - chemistry , alkylation , pyroglutamic acid , methylene , reagent , condensation , organic chemistry , amino acid , biochemistry , catalysis , physics , thermodynamics
The condensation of iminoether 7 , derived from pyroglutamic acid (4) , with active methylene reagents such as Meldrum's acid or methyl cyanoacetate, lead to β‐enaminoesters 2 . Solid‐liquid phase transfer N ‐alkylation of these compounds is described.