Reactions of 4‐aminocycloheptimidazoles with alkyl iodides, acyl chlorides, and α‐haloketones | Zendy

Ishida Noritoshi | Zendy; Imafuku Kimiaki | Zendy; Kurihara Teruo | Zendy

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Reactions of 4‐aminocycloheptimidazoles with alkyl iodides, acyl chlorides, and α‐haloketones

Author(s) -

Ishida Noritoshi,

Imafuku Kimiaki,

Kurihara Teruo

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290529

Subject(s) - chemistry , alkyl , phenacyl , medicinal chemistry , tricyclic , benzoyl chloride , halide , chloride , acylation , organic chemistry , catalysis

The reactions of 4‐amino‐2‐phenylcycloheptimidazole with alkyl iodides and α‐bromoketones gave respectively 1‐alkyl‐ and 1‐acetonyl‐ (or 1‐phenacyl)‐substituted cycloheptimidazol‐4(1 H )‐ones, while the reactions with acyl chlorides gave 4‐arylamino‐2‐phenylcycloheptimidazoles. On the other hand, 2,4‐diaminocycloheptimidazole were benzoylated with benzoyl chloride on the amino group at the 2‐ and/or 4‐position and reacted with α‐haloketones to give tricyclic 2‐substituted 9‐aminocyclohept[ d ]imidazo[1,2‐ a ]imidazoles.

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