Studies on pyridonecarboxylic acids  .  2 . Synthesis and antibacterial activity of 8‐substituted‐7‐fluoro‐5‐oxo‐5 H ‐thiazolo[3,2‐ a ]quinoline‐4‐carboxylic acids | Zendy

Segawa Jun | Zendy; Kitano Masahiko | Zendy; Kazuno Kenji | Zendy; Tsuda Masami | Zendy; Shirahase Ichiro | Zendy; Ozaki Masakuni | Zendy; Matsuda Masato | Zendy; Kise Masahiro | Zendy

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Studies on pyridonecarboxylic acids . 2 . Synthesis and antibacterial activity of 8‐substituted‐7‐fluoro‐5‐oxo‐5 H ‐thiazolo[3,2‐ a ]quinoline‐4‐carboxylic acids

Author(s) -

Segawa Jun,

Kitano Masahiko,

Kazuno Kenji,

Tsuda Masami,

Shirahase Ichiro,

Ozaki Masakuni,

Matsuda Masato,

Kise Masahiro

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290514

Subject(s) - chemistry , quinoline , antibacterial activity , intramolecular force , carboxylic acid , stereochemistry , medicinal chemistry , organic chemistry , bacteria , genetics , biology

A series of 8‐substituted‐7‐fluoro‐5‐oxo‐5 H ‐thiazolo[3,2‐ a ]quinoline‐4‐carboxylic acids was prepared and evaluated for antibacterial activity. These compounds were synthesized from ethyl 2‐mercaptoquinoline‐3‐carboxylates 17 which were obtained from anilines 11 by a route involving an intramolecular cyclization reaction.

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