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Studies on pyridonecarboxylic acids . 2 . Synthesis and antibacterial activity of 8‐substituted‐7‐fluoro‐5‐oxo‐5 H ‐thiazolo[3,2‐ a ]quinoline‐4‐carboxylic acids
Author(s) -
Segawa Jun,
Kitano Masahiko,
Kazuno Kenji,
Tsuda Masami,
Shirahase Ichiro,
Ozaki Masakuni,
Matsuda Masato,
Kise Masahiro
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290514
Subject(s) - chemistry , quinoline , antibacterial activity , intramolecular force , carboxylic acid , stereochemistry , medicinal chemistry , organic chemistry , bacteria , genetics , biology
A series of 8‐substituted‐7‐fluoro‐5‐oxo‐5 H ‐thiazolo[3,2‐ a ]quinoline‐4‐carboxylic acids was prepared and evaluated for antibacterial activity. These compounds were synthesized from ethyl 2‐mercaptoquinoline‐3‐carboxylates 17 which were obtained from anilines 11 by a route involving an intramolecular cyclization reaction.