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Palladium‐ or ruthenium‐catalyzed synthesis of 2‐phenylindoles
Author(s) -
Izumi Taeko,
Yokota Toshiko
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290509
Subject(s) - chemistry , ruthenium , palladium , catalysis , combinatorial chemistry , organic chemistry
Allyl α‐phenyl‐2‐aminophenethyl carbonates undergo a smooth decarboxylation‐dehydrogenation reaction to afford 2‐phenylindole derivatives in acetonitrile at 80° in the presence of palladium complex as catalyst. In the reaction, the ruthenium hydride complex showed more effective catalytic activities. 2‐Phenylindoles were also prepared from the corresponding α‐phenyl‐2‐aminophenethylalcohols and allyl methyl carbonate by ruthenium‐catalyzed cyclization.