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Cyclization of N ‐cyanovinyl‐lactam imines to condensed 4‐aminopyridines or substituted aminopyrazole
Author(s) -
Pätzel Michael,
Ushmajev Alexej,
Liebscher Jürgen,
Granik Vladimir,
Grisik Sofia,
Polievktov Mikhail
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290505
Subject(s) - chemistry , aminopyridines , lactam , intramolecular force , hydrazine (antidepressant) , medicinal chemistry , imine , catalysis , stereochemistry , organic chemistry , chromatography
N ‐Cyanovinyl‐lactam imines 2 react with hydrazine giving aminopyrazole 4a while lactam imine 3 is split off. Treatment of 2 with strong bases gives intramolecular cyclization to condensed 4‐aminopyridines 5 . The progress of reaction was observed by polarographic method.