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Synthesis of 3‐hetaryl‐4,5,6,7‐tetrahydrobenzo[ b ]thiophenes
Author(s) -
Sabnis R. W.,
Rangnekar D. W.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290463
Subject(s) - chemistry , thiophene , organic chemistry , carboxylate , medicinal chemistry
A novel efficient synthesis of 3‐hetaryl‐4,5,6,7‐tetrahydrobenzo[ b ]thiophenes was achieved by the cyclocondensation of ethyl 2‐amino‐4,5,6,7‐tetrahydrobenzo[6]thiophene‐3‐carboxylate with selected o ‐substituted aromatic amines or with alifatic, aromatic and heterocyclic acid hydrazides in the presence of polyphosphoric acid.