Research on nitrogen containing heterocyclic compounds.  XVIII . Synthesis of 9 H ‐pyrrolo[2,1‐ c ]‐ s ‐triazolo[4,3‐ a ][1,4]benzodiazepine, a novel tetracyclic ring of pharmaceutical interest | Zendy

Stefancich Giorgio | Zendy; Artico Marino | Zendy; Silvestri Romano | Zendy

Premium

Research on nitrogen containing heterocyclic compounds. XVIII . Synthesis of 9 H ‐pyrrolo[2,1‐ c ]‐ s ‐triazolo[4,3‐ a ][1,4]benzodiazepine, a novel tetracyclic ring of pharmaceutical interest

Author(s) -

Stefancich Giorgio,

Artico Marino,

Silvestri Romano

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290457

Subject(s) - chemistry , ring (chemistry) , intramolecular force , stereochemistry , benzodiazepine , chloride , medicinal chemistry , benzazepines , nitrogen , bicyclic molecule , lactam , organic chemistry , biochemistry , receptor

Reaction of di‐4‐morpholinylphosphinic chloride on 5,10‐dihydro‐9 H ‐pyrrolo[2,1‐ c ][1,4]benzodiazepin‐11‐one 9 afforded 11‐(di‐4‐morpholinylphosphinyloxy)‐5 H ‐pyrrolo[2,1‐ c ][1,4]benzodiazepine 10 . Displacement of di‐4‐morpholinylphosphinyloxy group of 10 by formylhydrazine with concomitant intramolecular cyclization led directly to 9 H ‐pyrrolo[2,1‐ c ]‐ s ‐triazolo[4,3‐ a ][1,4]benzodiazepine 7, a novel nitrogen heterocyclic ring of pharmaceutical interest. A new procedure for the synthesis of 9 is also described.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research