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A new synthetic route to 1,3,4‐oxadiazoles. Pharmacological study of some new derivatives
Author(s) -
Reynaud Pierre,
El Hamad Youssef,
Davrinche Catherine,
NguyenTriXuong Emmanuel,
Tran Gilles,
Rinjard Pierre
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290454
Subject(s) - chemistry , prodrug , position (finance) , combinatorial chemistry , stereochemistry , group (periodic table) , organic chemistry , biochemistry , finance , economics
2‐Substituted 1,3,4‐oxadiazoles have been examined as possible prodrugs of antidepressant hydrazides. A new method of synthesis of this heterocycle from thionoester and five new oxadiazoles substituted at the 2‐position by a 4‐pyridyl or 4‐aminophenyl group and at the 5‐position by a phenyl group are described.