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Synthesis and antibacterial activity of new 5‐substituted 1‐cyclopropyl‐6‐fluoro‐7‐piperazinyl‐1,4‐dihydro‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acids
Author(s) -
Remuzon Philippe,
Bouzard Daniel,
Di Cesare Pierre,
Dussy Christian,
Jacquet JeanPierre,
Jaegly Alexandre
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290453
Subject(s) - chemistry , antibacterial activity , carboxylic acid , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , bacteria , genetics , biology
The 5‐hydroxymethyl and the 5‐formyl‐1‐cyclopropyl‐6‐fluoro‐7‐piperazinyl‐1,4‐dihydro‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acids have been prepared via a 5‐trimethylsilyl group and were tested in vitro as potential antibacterials.