Synthesis of quinazoline derivatives through anionic cycloaddition reactions of methyl 2,4‐dimethoxy‐6‐methyl‐5‐pyrimidinecarboxylate with acetylenes and olefins | Zendy

Wada Akimori | Zendy; Yamamoto Hiromi | Zendy; Ohki Kazuhiro | Zendy; Nagai Sotoo | Zendy; Kanatomo Shoichi | Zendy

Premium

Synthesis of quinazoline derivatives through anionic cycloaddition reactions of methyl 2,4‐dimethoxy‐6‐methyl‐5‐pyrimidinecarboxylate with acetylenes and olefins

Author(s) -

Wada Akimori,

Yamamoto Hiromi,

Ohki Kazuhiro,

Nagai Sotoo,

Kanatomo Shoichi

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290439

Subject(s) - chemistry , cycloaddition , quinazoline , organic chemistry , medicinal chemistry , catalysis

The anionic cycloaddition of methyl 2,4‐dimethoxy‐6‐methyl‐5‐pyrimidinecarboxylate has been investigated. The lithium salt of methyl 2,4‐dimethoxy‐6‐methyl‐5‐pyrimidinecarboxylate, generated by deprotonation with lithium diisopropylamide in ether at – 70°, reacted smoothly with electron deficient acetylenes and olefins to give quinazoline derivatives in a single step.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research