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Tricyclic heteroaromatic systems. 5 H ‐1,2,4‐triazolo[5,1‐c][1,4]benzodiazepine
Author(s) -
Melani F.,
Cecchi L.,
Colotta V.,
Catarzi D.,
Filacchioni G.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290425
Subject(s) - tricyclic , chemistry , benzodiazepine , stereochemistry , receptor , biochemistry
Abstract The synthesis of the new tricyclic heteroaromatic system 5 H ‐1,2,4‐triazolo[5,1‐c][1,4]benzodiazepine, diazaanalogue of 5 H ‐pyrrolo[2,1‐c][1,4]benzodiazepine, which is the common feature of some antitumor antibiotics, is reported. The structure of the new tricyclic system and of some of its key intermediates is assigned by means of nuclear magnetic resonance studies.