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Metalation of diazines. VI . Metalation of pivaloylaminopyrazine and N‐t ‐butylpyrazinamide. Unusual regioselectivity in the metalation reaction
Author(s) -
Turck A.,
Plé N.,
Trohay D.,
Ndzi B.,
Quéguiner G.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290404
Subject(s) - metalation , regioselectivity , chemistry , pyrazine , medicinal chemistry , stereochemistry , organic chemistry , catalysis
Metalation of pivalamidopyrazine and N‐t ‐butylpyrazinamide were studied. For pivalamido pyrazine the yields were poor and some addition products were isolated. The metalation of t ‐butylpyrazinamide was successful and a curious regioselectivity was highlighted.
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