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Synthesis of some halogenated and disubstituted amino benzylacyclouridine derivatives
Author(s) -
Pan BaiChuan,
Chen ZhiHao,
Rowe Elizabeth C.,
Chu ShihHsi
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290402
Subject(s) - chemistry , pyrimidine , hydroxymethyl , combinatorial chemistry , stereochemistry , organic chemistry
1′‐Halogenomethyl, 1′‐azidomethyl and 1′‐disubstituted aminomethyl derivatives of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacyclouridine) were synthesized in the course of our studies of benzylacyclouridines. Two new and more convenient preparations of the previously known aminomethyl‐and hydroxymethyl‐parent compounds of these two series, AM‐BAU, AM‐BBAU and HM‐BBAU are also reported. These compounds were synthesized during a search for potential antiviral agents and pyrimidine phosphorylase inhibitors.