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On the synthesis of 3,4‐dihydro‐2 H ‐1,2‐benzothiazine 1,1‐dioxides
Author(s) -
Camoutsis Charalambos,
Catsoulacos Panayotis
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290248
Subject(s) - benzothiazine , chemistry , diborane , chloride , hydrolysis , medicinal chemistry , organic chemistry , boron
The 3,4‐dihydro‐2 H ‐1,2‐benzothiazine 1,1‐dioxides were prepared by reduction of the corresponding 1,2‐benzothiazin‐2‐ones with diborane. The latter were obtained by the action of primary amines on 4,5‐dimethoxy‐2‐carbomethoxymethylbenzenesulfonyl chloride followed by basic hydrolysis and cyclization of the formed 4,5‐dimethoxy‐2‐carbomethoxymethylbenezenesulfonamides.