Synthesis of 3‐(6‐alkylaminopurin‐9‐yl)‐2,3‐dideoxy‐D‐ thero ‐pentopyranoses and their reduction to 3‐(6‐alkylaminopurin‐9‐yl)‐2,3‐dideoxy‐D‐ thero ‐pentitols | Zendy

HjulerNielsen Hans Peter | Zendy; Pedersen Hans | Zendy; Hansen Henning Bue | Zendy; Pedersen Erik B. | Zendy; Nielsen Claus | Zendy

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Synthesis of 3‐(6‐alkylaminopurin‐9‐yl)‐2,3‐dideoxy‐D‐ thero ‐pentopyranoses and their reduction to 3‐(6‐alkylaminopurin‐9‐yl)‐2,3‐dideoxy‐D‐ thero ‐pentitols

Author(s) -

HjulerNielsen Hans Peter,

Pedersen Hans,

Hansen Henning Bue,

Pedersen Erik B.,

Nielsen Claus

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290237

Subject(s) - chemistry , reduction (mathematics) , stereochemistry , combinatorial chemistry , medicinal chemistry , geometry , mathematics

3‐(6‐Alkylaminopurin‐9‐yl)‐2,3‐dideoxy‐D‐threo‐pentopyranoses 3 were prepared by condensation of unprotected 2‐deoxy‐D‐ribose (2) with N 6 ‐alkyladenines 1 in a phosphorus pentoxide reagent mixture. Reduction of the pentoses 3 gave the corresponding 3‐(6‐alkylaminopurin‐9‐yl)‐2,3‐dideoxy‐D‐ threo ‐pentitols 4. The structures of 3 and 4 were determined by 13 C nmr, 1 H nmr and 2D 1 H nmr (COSY).

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