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Short synthesis of tryptophane and β‐carboline derivatives by reaction of indoles with N ‐(diphenylmethylene)‐α,β‐didehydroamino acid esters
Author(s) -
Spadoni Gilberto,
Balsamini Cesarino,
Bedini Annalida,
Duranti Ermanno,
Tontini Andrea
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290205
Subject(s) - chemistry , catalysis , organic chemistry , indole test , medicinal chemistry
The ethylaluminum dichloride catalyzed Michael‐type addition of indoles 1a‐h to the N ‐(diphenylmethylene)‐α,β‐didehydroamino acid esters 2a‐c allows a new synthesis of β‐methyltryptophanes 41,m and a new route for 1,1‐diphenyl‐3‐carbalkoxy‐1,2,3,4‐tetrahydro‐β‐carbolines 5a‐m.