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1,3‐dipolar cycloaddition of nitrile oxides with 2‐phenyl‐4‐ethoxymethylene‐5(4 H )‐oxazolone
Author(s) -
CoutouliArgyropoulou E.,
Thessalonikeos E.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290146
Subject(s) - chemistry , oxazolone , nitrile , cycloaddition , 1,3 dipolar cycloaddition , nucleophile , medicinal chemistry , organic chemistry , catalysis
2‐Phenyl‐4‐ethoxymethylene‐5(4 H )‐oxazolone 1 reacts regioselectively with nitrile oxides to give cycloadducts 3 . Reactions of the cycloadducts 3 with nucleophiles lead to 4‐aminoisoxazole derivatives.