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Synthesis of isomeric series of aryltetrahydrobenz‐isoxazoles and arylcyclopentisoxazoles
Author(s) -
Fos Empar,
Borràs Liset,
Gasull Maria,
Mauleón David,
Carganico Germano
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290137
Subject(s) - isoxazole , chemistry , aryl , ring (chemistry) , series (stratigraphy) , stereochemistry , organic chemistry , combinatorial chemistry , medicinal chemistry , paleontology , alkyl , biology
Four series of potential PAF‐antagonists in which the isoxazole nucleus is condensed with a polyhydrogenated five‐ or six‐carbon ring were prepared. The synthesis of the compounds 3‐aryl‐4,5,6,7‐tetrahydrobenz[ c ]isoxazoles 1 , 3‐arylcyclopent[ c ]isoxazoles 2 , 3‐aryl‐4,5,6,7‐tetrahydrobenz[ d ]isoxazoles 3 , and 3‐arylcyclopent[ d ]isoxazoles 4 , required an extensive optimization and comparison of the methods available in the literature.