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Assembled systems [X‐azolopyridine][quinoline]. Bases and salts
Author(s) -
Savarino Piero,
Viscardi Guido,
Barni Ermanno,
Di Modica Gaetano,
Montoneri Enzo,
Quagliotto Pierluigi
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290134
Subject(s) - chemistry , quinoline , pyridine , iodide , methyl iodide , medicinal chemistry , organic chemistry
A series of bases containing X‐azolopyridines (X = O, NH) and methylquinolines, assembled in different ways, was prepared by reaction of methylquinolinecarboxylic acids (or carboxamides) with diamino (or hydroxyamino) pyridines. The bases were quaternized with methyl iodide. The physical and spectroscopic data of both the bases and the salts were correlated and compared with those of [X‐azolopyridine][pyridine] systems previously studied. The structure of the salts was markedly influenced by a balance of basicity‐hindrance factors in the heteroaromatic substrates.