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A Convenient and efficient method for the preparation of 6‐Acyl‐2(3 H )‐benzoxazolones
Author(s) -
Aichaoui Hocine,
Lesieur Daniel,
Hénichart JeanPierre
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290131
Subject(s) - chemistry , acylation , dimethylformamide , regioselectivity , chloride , organic chemistry , catalysis , combinatorial chemistry , solvent
Benzoxazolinone derivatives have been found to exhibit various pharmacological properties and 6‐acyl‐2(3 H )‐benzoxazolones are considered as key starting materials for the preparation of these compounds. Reported here are the optimal conditions for a regioselective acylation at the 6‐position of the benzoxazolinone ring. A general method leading to the expected products in excellent yields consists in using a mixture of aluminum chloride‐dimethylformamide as catalyst and acid anhydrides or chlorides as acylating agents.