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Synthesis and anticonvulsant activity of 3‐alkyl‐3,4‐dihydro‐2(1 H )‐quinazolinones
Author(s) -
Kornet Milton J.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290117
Subject(s) - chemistry , quinazolinone , anticonvulsant , isopropyl , anthranilic acid , alkyl , stereochemistry , biological activity , medicinal chemistry , organic chemistry , epilepsy , biochemistry , in vitro , neuroscience , biology
Previously we reported the potent anticonvulsant activity of 3‐dimethylamino‐3,4‐dihydro‐2(1 H )‐quinazolinone. In this report, a series of 3‐alkyl‐3,4‐dihydro‐2(1 H )‐quinazolinones was synthesized in three steps from isatoic anhydrides or an anthranilic acid. Structure/activity investigations revealed optimal activity for the 3‐isopropyl and 3‐cyciohexyl analogs. These compounds were effective against seizures induced by maximal electroshock.