Enzymatic hydrolysis of heterocyclic nitriles | Zendy

Klempier Norbert | Zendy; De Raadt Anna | Zendy; Griengl Herfried | Zendy; Heinisch Gottfried | Zendy

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Enzymatic hydrolysis of heterocyclic nitriles

Author(s) -

Klempier Norbert,

De Raadt Anna,

Griengl Herfried,

Heinisch Gottfried

Publication year - 1992

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570290115

Subject(s) - chemistry , indole test , hydrolysis , enzymatic hydrolysis , pyrimidine , biocatalysis , nitrile , organic chemistry , combinatorial chemistry , dehydrogenation , enzyme , stereochemistry , catalysis , reaction mechanism

Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp . Pyrimidine‐2‐carbonitrile ( 2a ) and 3‐chloropyridazine‐4‐carbonitrile ( 4a ) were converted into the corresponding amides while from 2‐ethoxycarbonyl‐4‐pyridinecarbonitrile ( 1a ), 6‐methylpyridazine‐3‐carbonitrile ( 3a ), 3‐chloropyridazine‐4‐carbonitrile ( 4a ), 3‐ethoxycarbonyl‐4,5‐dihydroisoxazole‐5‐carbonitrile ( 8a ), indole‐3‐carbonitrile ( 9a ) and indole‐3‐ylacetonitrile ( 10a ) the acids were formed.

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