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Enzymatic hydrolysis of heterocyclic nitriles
Author(s) -
Klempier Norbert,
De Raadt Anna,
Griengl Herfried,
Heinisch Gottfried
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290115
Subject(s) - chemistry , indole test , hydrolysis , enzymatic hydrolysis , pyrimidine , biocatalysis , nitrile , organic chemistry , combinatorial chemistry , dehydrogenation , enzyme , stereochemistry , catalysis , reaction mechanism
Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp . Pyrimidine‐2‐carbonitrile ( 2a ) and 3‐chloropyridazine‐4‐carbonitrile ( 4a ) were converted into the corresponding amides while from 2‐ethoxycarbonyl‐4‐pyridinecarbonitrile ( 1a ), 6‐methylpyridazine‐3‐carbonitrile ( 3a ), 3‐chloropyridazine‐4‐carbonitrile ( 4a ), 3‐ethoxycarbonyl‐4,5‐dihydroisoxazole‐5‐carbonitrile ( 8a ), indole‐3‐carbonitrile ( 9a ) and indole‐3‐ylacetonitrile ( 10a ) the acids were formed.