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Synthesis of 5,6,8,9,14,14a‐hexahydroisoquino[1,2‐ b ][3]benzazepines
Author(s) -
Kim Dong H.
Publication year - 1992
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570290103
Subject(s) - chemistry , benzazepines , azepine , isoquinoline , ring (chemistry) , intramolecular force , benzazepine , stereochemistry , lactam , organic chemistry
Syntheses of 5,6,8,9,14,14a‐hexahydroisoquino[1,2‐ b ][3]benzazepine‐2,3,11,12‐tetrol and related compounds are described. Key steps involve an initial construction of the isoquinoline ring under the Bischler‐Napieralski conditions, which is followed by the building of the azepine ring via an intramolecular lactam formation on to the isoquinoline nucleus.