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Synthesis of 2‐guanyl‐4‐(3‐substituted‐phenyl)thiazoles with potent histamine H 2 ‐antagonism activity
Author(s) -
Santilli Arthur A.,
Scotese Anthony C.,
Morris Robert L.,
Bell Stanley C.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280839
Subject(s) - chemistry , antagonism , histamine , stereochemistry , ring (chemistry) , pharmacology , organic chemistry , receptor , biochemistry , medicine
The syntheses of novel 2‐guanyl‐4‐(3‐substituted‐phenyl)thiazoles showing potent histamine H 2 ‐antagonism activity is reported. The most potent compound is 17 where the substitution at the 3‐position of the phenyl ring is an N ‐methylamidino function.