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Synthesis of 4‐hydroxy‐3‐triftuoromethylpyrazoles
Author(s) -
Iwata Satoru,
Namekata Junji,
Tanaka Kiyoshi,
Mitsuhashi Keiryo
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280830
Subject(s) - chemistry , electrophile , trifluoromethyl , group (periodic table) , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , alkyl
Trifluoroacetaldehyde hydrazones are condensed with glyoxals to give 4‐hydroxy‐3‐trifluoromethylpyrazoles, the reaction offering a novel route to 4‐hydroxypyrazoles carrying trifluoromethyl group. The 4‐hydroxyl group was easily converted to its derivatives by the reaction with various electrophiles.