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Synthesis of 7‐ethyl‐4,7‐dihydro‐4‐oxo‐2‐(4‐pyridinyl)thieno[2,3‐ b ]pyridine‐5‐carboxylic acid
Author(s) -
Bacon Edward R.,
Daum Sol J.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280826
Subject(s) - chemistry , nalidixic acid , pyridine , carboxylic acid , antibacterial activity , antibacterial agent , stereochemistry , medicinal chemistry , organic chemistry , antibiotics , bacteria , ciprofloxacin , biochemistry , biology , genetics
7‐Ethyl‐4,7‐dihydro‐4‐oxo‐2‐(4‐pyridinyl)thieno[2,3‐ b ]pyridine‐5‐carboxylic acid ( 4 ), an analog of nalidixic acid, was synthesized in seven steps starting from commercially available 4‐methylpyridine. Bacterial susceptibility to compound 4 was tested and the title compound was found to exhibit only weak antibacterial activity against a variety of pathogens including S. Aureus, E. Coli and P. Aeruginosa .