Synthesis of 7‐ethyl‐4,7‐dihydro‐4‐oxo‐2‐(4‐pyridinyl)thieno[2,3‐ b ]pyridine‐5‐carboxylic acid | Zendy

Bacon Edward R. | Zendy; Daum Sol J. | Zendy

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Synthesis of 7‐ethyl‐4,7‐dihydro‐4‐oxo‐2‐(4‐pyridinyl)thieno[2,3‐ b ]pyridine‐5‐carboxylic acid

Author(s) -

Bacon Edward R.,

Daum Sol J.

Publication year - 1991

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570280826

Subject(s) - chemistry , nalidixic acid , pyridine , carboxylic acid , antibacterial activity , antibacterial agent , stereochemistry , medicinal chemistry , organic chemistry , antibiotics , bacteria , ciprofloxacin , biochemistry , biology , genetics

7‐Ethyl‐4,7‐dihydro‐4‐oxo‐2‐(4‐pyridinyl)thieno[2,3‐ b ]pyridine‐5‐carboxylic acid ( 4 ), an analog of nalidixic acid, was synthesized in seven steps starting from commercially available 4‐methylpyridine. Bacterial susceptibility to compound 4 was tested and the title compound was found to exhibit only weak antibacterial activity against a variety of pathogens including S. Aureus, E. Coli and P. Aeruginosa .

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