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On the synthesis of geminally functionalized heterocyclic aminocarboxylic acid esters
Author(s) -
CoutouliArgyropoulou E.,
Thessalonikeos E.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280824
Subject(s) - chemistry , regioselectivity , cycloaddition , 1,3 dipolar cycloaddition , organic chemistry , combinatorial chemistry , catalysis
The title compounds 5 can be easily obtained by two alternative procedures: 1,3‐dipolar cycloaddition to benzamidocinnamates 3 prepared by methanolysis of the corresponding oxazolones 1 or methanolysis of the spirooxazolones 4 synthesized by 1,3‐dipolar cycloaddition to oxazolones 1 . Both reaction sequences show the same stereo and regioselectivity.