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A convenient route to diazepines by intramolecular cyclisation of carbonylazides
Author(s) -
Daich Abdelali,
Povazanec Frantisek,
Decroix Bernard
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280818
Subject(s) - chemistry , acetamide , intramolecular force , acetic acid , lactam , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
The appropriate substituted carbonylazides I treated with warm acetic acid give the corresponding acetamide IV or the cyclic lactam VI . This is a convenient route to 10,11‐Dihydro‐5 H ‐pyrrolo[1,2‐ a ][1,4]‐benzodiazepin‐11‐one and 10,11‐Dihydro‐4 H ‐thieno[2,3‐ e ]pyrrolo[1,2‐ a ][1,4]diazepin‐10‐one.
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