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Synthesis, crystal structure determination and pharmacological activity of 7,8,3′,4′‐tetramethoxyisoflavone
Author(s) -
Domínguez Esther,
Lete Esther,
Villa MaríaJesús,
Igartua Amaia,
Sotomayor Nuria,
Arrieta Juan M.,
Berisa Agustin,
Labeaga Luis,
Orjales Aurelio,
Germain Gabriel,
Nastopoulos Vassilios
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280815
Subject(s) - chemistry , isoflavones , alkylation , crystal structure , carrageenan , stereochemistry , structure–activity relationship , biological activity , organic chemistry , in vitro , biochemistry , catalysis
7 The8,3′,4′‐tetramethoxyisoflavone 2 was synthesized and its structure confirmed by X‐ray crystallographic analysis. Pharmacological screening was carried out with this compound in order to assess its pharmacological profile. Isoflavone 2 possessed antiinflamatory activity in the carrageenan oedema test, with a dose‐effect relationship comparable to that of hydroxylated flavonoids. It is noteworthy that 2 is one of the few isoflavones efficient as antiinflammatory with complete alkylation of hydroxyl groups.