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Studies on the constituents of bocconia cordata . IV . Transformation of sanguinarine into bocconine
Author(s) -
Konda Yaeko,
Urano Mieko,
Harigaya Yoshihiro,
Onda Masayuki
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280806
Subject(s) - sanguinarine , chemistry , transformation (genetics) , traditional medicine , stereochemistry , alkaloid , biochemistry , gene , medicine
Nitration of ethoxysanguinarine with equimolar potassium nitrate and sulfuric acid, followed by treatment with sodium hydroxide and methanol, gives 10‐nitromethoxysanguinarine. Successive hydrogenation, diazotization and methanolysis convert 10‐nitromethoxysanguinarine into bocconine.