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Selective N ‐1 alkylation of unsymmetrically substituted pyrazoles
Author(s) -
Malhotra Nageshwar,
FältHansen Birgitte,
Becher Jan
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280805
Subject(s) - chemistry , alkylation , pyrazole , medicinal chemistry , position (finance) , stereochemistry , organic chemistry , catalysis , finance , economics
A series of C ‐substituted pyrazoles have been N ‐alkylated. The alkylation occurs preferentially at the N ‐1 position when a tert ‐butyl group is present at the pyrazole C‐3 position.
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