Identification of an impurity in synthetically prepared GAZT: 4″,5″‐dehydro‐GAZT | Zendy

Koble Cecilia S. | Zendy; Hall William R. | Zendy; Styles Virgil L. | Zendy; Rideout Janet L. | Zendy; Minick Doug | Zendy; Cichetti James | Zendy; Johnson Robert L. | Zendy; Crouch Ronald C. | Zendy; Martin Gary E. | Zendy

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Identification of an impurity in synthetically prepared GAZT: 4″,5″‐dehydro‐GAZT

Author(s) -

Koble Cecilia S.,

Hall William R.,

Styles Virgil L.,

Rideout Janet L.,

Minick Doug,

Cichetti James,

Johnson Robert L.,

Crouch Ronald C.,

Martin Gary E.

Publication year - 1991

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570280724

Subject(s) - chemistry , impurity , mass spectrometry , chromatography , high performance liquid chromatography , glucuronide , organic chemistry , metabolite , biochemistry

A minor impurity was recorded by hplc during the final purification of synthetically prepared samples of the 5′‐0‐glucuronide of azidothymidine (GAZT). Following isolation of a small quantity of this impurity by hplc, elucidation of the structure was undertaken. A combination of two‐dimensional nmr methods in conjunction with infrared spectroscopy and mass spectrometry were utilized to unequivocally identify the impurity as the 4″,5″‐dehydro‐5′‐ O ‐glucuronide of AZT (DGAZT).

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