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Synthesis and properties of 5‐aroylamino‐2 H ‐1,2,4‐thiadiazol‐3‐ones
Author(s) -
Cho Nam Sook,
Shon Hyun Il,
Párkányi Cyril
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280714
Subject(s) - chemistry , tautomer , lactam , bromine , stereochemistry , computational chemistry , medicinal chemistry , organic chemistry
5 ‐Aroylamino‐2 H ‐1,2,4‐thiadiazol‐3‐ones 3 were obtained from the corresponding 1‐aroyl‐2‐thiobiurets 2 by oxidative cyclization with bromine. 5 ‐Aroylamino‐2 H ‐1,2,4‐thiadiazol‐3‐ones 3 can exist in two tautomeric forms a lactam form and a lactim form. On the basis of the 13 C nmr spectra and additional experimental information, it has been established that the stable form, in which these compounds exist, is the lactam form.