Premium
Synthesis and properties of a bilirubin analog with propionic acid groups replaced by carboxyl
Author(s) -
Byun YoungSeok,
Lightner David A.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280707
Subject(s) - chemistry , bilirubin , organic chemistry , group (periodic table) , stereochemistry , propionates , medicine , gastroenterology
The unnatural bile pigment analog of bilirubin‐IXα, 2,3,7,13,17,18‐hexamethyl‐(10 H ,21 H ,23 H ,24 H )‐bilin‐1,19‐dione‐8,12‐dicarboxylic acid (1), was synthesized as its diethyl ester by coupling 4,4′‐dimethyl‐3,3′‐dicarboethoxydipyrrylmethane‐5,5′‐dialdehyde with 3,4‐dimethylpyrrolin‐2‐one.