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Identification of some isomeric 3,5‐unsymmetrically substituted 1‐aroyl‐pyrazole derivatives by NMR spectroscopy
Author(s) -
Mitkidou Sophia,
Papadopoulos Stelios,
StephanidouStephanatou Julia
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280605
Subject(s) - chemistry , pyrazole , ring (chemistry) , nuclear magnetic resonance spectroscopy , stereochemistry , carbon 13 nmr , nmr spectra database , spectroscopy , chemical shift , medicinal chemistry , organic chemistry , spectral line , physics , quantum mechanics , astronomy
The 1 H and 13 C nmr chemical shifts are used for the structural assignment of isomeric 1‐aroyl‐4,5‐dihydro‐5‐hydroxy‐4,4‐dimethyl‐1 H ‐pyrazoles 1 unsymmetrically substituted with phenyl or methyl in the 3,5‐positions of the pyrazole ring. The 1 H nmr spectra of 1‐aroyl‐ or 1‐acetyl‐4‐methyl‐1 H ‐pyrazoles 2 are useful in structure elucidation of unsymmetrically 3‐ or 5‐methyl substituted derivatives.