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A convenient synthesis of ethyl 2‐(4‐nitrophenyl)‐3,4‐disubstituted and c ‐fused thiophene‐5‐carboxylates
Author(s) -
Rangnekar D. W.,
Mavlankar S. V.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280546
Subject(s) - chemistry , sodium ethoxide , thiophene , ethanol , condensation , organic chemistry , sodium , medicinal chemistry , physics , thermodynamics
A convenient one step synthesis of the hitherto unknown ethyl 2‐(4‐nitrophenyl)‐3,4‐disubstituted and c ‐fused thiophene‐5‐carboxylates was achieved by the condensation of ethyl 4‐nitrobenzylthioacetate with a variety of 1,2‐dicarbonyl compounds using sodium ethoxide in refluxing ethanol.