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A method for the synthesis of racemic and optically active 2‐substituted 9‐(2′,3′‐dihydroxypropyl)‐8‐azahypoxanthines and 8‐azaadenines
Author(s) -
Barili P. L.,
Biagi G.,
Giorgi I.,
Livi O.,
Scartoni V.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280529
Subject(s) - chemistry , adenosine deaminase , optically active , acetonide , stereochemistry , combinatorial chemistry , organic chemistry , enzyme , triamcinolone acetonide , medicine , surgery
Several 9‐(2′,3′‐ O ‐isopropylidene)‐ and 9‐(2′,3′‐dihydroxypropyl)‐8‐azahypoxanthines and 8‐azaadenines were synthesized by a “one pot” method starting from the acetonide of racemic or ( S )‐1‐azido‐2,3‐dihydroxypropane, obtained from D‐mannitol. 9‐(2′,3′‐Dihydroxypropyl)‐8‐azapurines were tested as adenosine deaminase inhibitors.