A method for the synthesis of racemic and optically active 2‐substituted 9‐(2′,3′‐dihydroxypropyl)‐8‐azahypoxanthines and 8‐azaadenines | Zendy

Barili P. L. | Zendy; Biagi G. | Zendy; Giorgi I. | Zendy; Livi O. | Zendy; Scartoni V. | Zendy

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A method for the synthesis of racemic and optically active 2‐substituted 9‐(2′,3′‐dihydroxypropyl)‐8‐azahypoxanthines and 8‐azaadenines

Author(s) -

Barili P. L.,

Biagi G.,

Giorgi I.,

Livi O.,

Scartoni V.

Publication year - 1991

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570280529

Subject(s) - chemistry , adenosine deaminase , optically active , acetonide , stereochemistry , combinatorial chemistry , organic chemistry , enzyme , triamcinolone acetonide , medicine , surgery

Several 9‐(2′,3′‐ O ‐isopropylidene)‐ and 9‐(2′,3′‐dihydroxypropyl)‐8‐azahypoxanthines and 8‐azaadenines were synthesized by a “one pot” method starting from the acetonide of racemic or ( S )‐1‐azido‐2,3‐dihydroxypropane, obtained from D‐mannitol. 9‐(2′,3′‐Dihydroxypropyl)‐8‐azapurines were tested as adenosine deaminase inhibitors.

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