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The synthesis of substituted [1]benzothieno[2,3‐ c ]quinolines and their N ‐methyl quaternary salts
Author(s) -
Luo JiannKuan,
Musmar M. J.,
Castle Raymond N.
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280524
Subject(s) - chemistry , medicinal chemistry , stereochemistry
Four substituted [1]benzothieno[2,3‐ c ]quinolines 14a‐14d were prepared by photocyclization of the appropriate carboxamides 8a‐8d to the corresponding [1]benzothieno[2,3‐ c ]quinolin‐6(5 H )‐ones 12a‐12d followed by chlorination to 6‐chloro[1]benzothieno[2,3‐ c ]quinolines 13a‐13d and dechlorination resulting in the title compounds. Treatment of 14a‐14d with iodomethane furnished the corresponding N ‐methyl quaternary salts 5a‐5d .